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Studies have shown that when amyloid-beta and tau are increased, the cells ability to neutralize oxidative stress and mitochondria specific ROS is decreased leading to further tau hyperphosphorylation and neurodegeneration (Alavi Naini and Soussi-Yanicostas 2015)

Comprehensive analysis of heat and water exchanges in the human lungs

By interfering with this hyperactivated process, P140 reduces the presentation of self-antigens to T cells, effectively dampening the autoimmune drive at one of its key control points

The peptides likely work through overlapping but not identical pathways, so combining them could produce additive effects

Animal experiments All mouse experiments were approved by the Institutional Animal Care and Use Committee at Fudan University and Shanghai Institute of Biochemistry and Cell Biology